COAGULAÇAO
Informaçao geral
Directorios
Textos
![](https://upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Coagulation_in_vivo.png/400px-Coagulation_in_vivo.png)
![](https://upload.wikimedia.org/wikipedia/commons/thumb/4/42/Classical_blood_coagulation_pathway.png/350px-Classical_blood_coagulation_pathway.png)
![File:Rapaport Coagulation Cascade.svg](https://upload.wikimedia.org/wikipedia/commons/thumb/5/55/Rapaport_Coagulation_Cascade.svg/776px-Rapaport_Coagulation_Cascade.svg.png)
![The clotting cascade](http://www.frca.co.uk/images/clotting_cascade.gif)
![](http://atvb.ahajournals.org/content/27/8/1687/F1.medium.gif)
Genetica da coagulação
Informaçao especializada
Activador do plasminogenio tecidular
![File:Fibrinolysis.png](https://upload.wikimedia.org/wikipedia/commons/0/0e/Fibrinolysis.png)
Deficiencia em activador do plasminogenio
Ver inibidores da actividade do
plasminogenio
Agregaçao plaquetaria
![](http://www.pharmacorama.com/Rubriques/Output/images/Coagulationa.gif)
Antiplasmina ( inibidor da plasmina)
![](http://www.haemtech.com/images2/Alpha2.jpg)
Antitrombina
![Antithrombin sites of action.](http://img.medscapestatic.com/pi/meds/ckb/84/36384tn.jpg)
Deficiencia em antitrombina
Bernard- Soulier
Bradiquinina
Receptor da bradiquinina
Buerger
Ver trombangeite obliterante
Calicreina
![](https://upload.wikimedia.org/wikipedia/commons/0/0e/Fibrinolysis.png)
Christmas
Deficiência do factor Christmas
– hemofilis B
Coagulaçao e gravidez
![Chemical Changes During Pregnancy](https://openanesthesia.wpengine.com/wp-content/uploads/2015/03/Chemical-Changes-During-Pregnancy.png)
Coagulaçao intravascular
disseminada
![](https://upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Coagulation_full.svg/400px-Coagulation_full.svg.png)
Cofactor II da heparina
Dermatite purpúrica pigmentada
![Pigmented Purpuric Dermatosis](http://m.patient.media/images/purpura_annularis_telangiectodes.jpg)
![An external file that holds a picture, illustration, etc.
Object name is ad-24-363-g002.jpg](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412251/bin/ad-24-363-g002.jpg)
Fibrina
![](https://upload.wikimedia.org/wikipedia/commons/thumb/3/31/Stabilisation_de_la_fibrine_par_le_factor_XIII.png/220px-Stabilisation_de_la_fibrine_par_le_factor_XIII.png)
![](http://cdn.rcsb.org/pdb101/motm/images/83_1m1j-1fzc.jpg)
Factores da coagulaçso
![](https://upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Coagulation_in_vivo.png/400px-Coagulation_in_vivo.png)
FACTOR
|
NAME
|
SOURCE
|
PATHWAY
|
I
|
Fibrinogen
|
Liver
|
Common
|
II
|
Prothrombin (enzyme)
|
Liver *
|
Common
|
III
|
Thromboplastin
|
Released by damaged cells
|
Extrinsic
|
III
|
Thromboplastin
|
Released by platelets
|
Intrinsic
|
IV
|
Calcium ions
|
Bone and gut
|
Entire process
|
V
|
Proaccererin
(heat labile cofactor) |
Liver and Platelets
|
Extrinsic and Intrinsic
|
VII
|
Proconvertin (enzyme)
|
Liver *
|
Extrinsic
|
VIII
|
Anti-hemolytic factor(cofactor)
|
Platelets and endothelium
|
Intrinsic
|
IX
|
Christmas factor(plasma
thromboplastin component)
|
Liver *
|
Intrinsic
|
X
|
Stuart Prower factor (enzyme)
|
Liver *
|
Extrinsic and Intrinsic
|
XI
|
Plasma thromboplastin antecedent (enzyme)
|
Liver
|
Intrinsic
|
XII
|
Hageman
factor
|
Liver
|
Intrinsic; also activates plasmin
|
XIII
|
Fibrin stabilizing factor
|
Liver
|
Retards fibrinolysis
|
*vitamin K dependente
Factor III, factor tecidular ou
tromboplastina
https://en.wikipedia.org/wiki/Tissue_factor![](https://upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Coagulation_full.svg/300px-Coagulation_full.svg.png)
Deficiencia em factor III
Factor IV
Factor V (Leiden)
Deficiencia em fsactor V
Trombofilia do factor V
Ver TROMBOFILIS
Factor VII ou proconvertina
Deficiencia em factor VII
Factor VIIa
Factor VIII
![Fig. 1.](http://d3md5dngttnvbj.cloudfront.net/content/bloodjournal/92/11/3983/F1.medium.gif)
Deficiencia do factor VIII
Factor VIII aumentado
Factor IX ( Christmas)
.Ver CHRISTMAS
Factor X ( Stuart –
Power)
![](https://upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Coagulation_in_vivo.png/350px-Coagulation_in_vivo.png)
Deficiencia em factor X
Factor Xa
Factor XI
![Factor XI deficiency. Graph depicts factor deficie](http://img.medscapestatic.com/pi/meds/ckb/38/36838tn.jpg)
Drficiencia em factor XI
Factor XII ( Hageman)
![](https://upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Coagulation_full.svg/400px-Coagulation_full.svg.png)
![Figure 3](http://d3md5dngttnvbj.cloudfront.net/content/bloodjournal/120/22/4296/F3.medium.gif)
Deficiencia em factor XII
Factor XIII
![](https://upload.wikimedia.org/wikipedia/commons/thumb/3/31/Stabilisation_de_la_fibrine_par_le_factor_XIII.png/260px-Stabilisation_de_la_fibrine_par_le_factor_XIII.png)
![Activation of factor XIII (FXIII) by thrombin and](http://img.medscapestatic.com/pi/meds/ckb/88/44288tn.jpg)
Deficiencia bem factor XIII
Fibrinogenio
![](https://www.ebi.ac.uk/interpro/potm/2006_11/Page1_files/image008.jpg)
![](https://www.ebi.ac.uk/interpro/potm/2006_11/Page1_files/image010.jpg)
![blood: coagulation](http://media-2.web.britannica.com/eb-media/10/386x370x6710-004-65A2759E.jpg.pagespeed.ic.PsRl32uzKZ.jpg)
Deficiencia em fibrinogenio
Fibrinolise
![](http://www.pharmacorama.com/Rubriques/Output/images/Coagulationa6_clip_image002.gif)
Hemofilia
·
Haemophilia A is a recessive X-linked genetic disorder involving a
lack of functional clotting Factor VIII and represents 80% of haemophilia
cases.
·
Haemophilia B is a recessive X-linked genetic disorder involving a
lack of functional clotting Factor IX. It comprises approximately 20%
of haemophilia cases.[11]
·
Haemophilia C is an autosomal genetic disorder (i.e. not X-linked) involving a lack of
functional clotting Factor XI. Haemophilia C is not completely recessive, asheterozygous individuals also show increased bleeding.[12]
![](http://www.cdc.gov/ncbddd/hemophilia/images/hemophilia-genes.jpg)
Hipercoagulaçao
![Blood clot formation](https://my.clevelandclinic.org/ccf/media/Images/heart/thrombusformation2.jpg?la=en)
Homocistinemia e coagulação
Inibidor da plasmina (antiplasmina)
![](http://www.haemtech.com/images2/Alpha2.jpg)
Deficiencia da antiplasmina
Inibidores da via do factor tecidular
![](https://www.ebi.ac.uk/interpro/potm/2006_3/Page2_files/image004.jpg)
Alfa 2 Macroglobulina
![](https://upload.wikimedia.org/wikipedia/commons/0/0e/Fibrinolysis.png)
Deficiencia em alfa2 macroglobulina
May- Hegglin
![Figure1](http://d3md5dngttnvbj.cloudfront.net/content/bloodjournal/119/2/328/F1.medium.gif)
Plaquetas
![](https://upload.wikimedia.org/wikipedia/commons/thumb/8/84/1908_Platelet_Development.jpg/220px-1908_Platelet_Development.jpg)
![Normal hemostasis.](http://img.medscapestatic.com/pi/meds/ckb/22/13522tn.jpg)
Plasmina
![](https://upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Fibrinolysis.png/300px-Fibrinolysis.png)
Plasminogenio
Activaçao do plasminogenio
![](https://upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Fibrinolysis.png/250px-Fibrinolysis.png)
![Figure](http://stroke.ahajournals.org/content/41/10_suppl_1/S39/F1.small.gif)
Deficiencia em plasminogenio
Inibidor do activador do plasminogenio
![](https://upload.wikimedia.org/wikipedia/commons/0/0e/Fibrinolysis.png)
Pre-calicreina
Deficiencia em pre-calicreina
Proteinas C e S
![](https://upload.wikimedia.org/wikipedia/commons/thumb/9/98/Protein_C_1D_schematic.png/410px-Protein_C_1D_schematic.png)
Deficiencia em proteínas C
Deficiencia congénita em proteínas C e S
Deficiencia em proteína S
Proteina Z
Deficiencia em proteína Z
Protrombina
![blood: coagulation](http://media-2.web.britannica.com/eb-media/10/386x370x6710-004-65A2759E.jpg.pagespeed.ic.PsRl32uzKZ.jpg)
Deficiencia em protrombina
Mutaçao do gene da protrombina
Tempo de protrombina
Purpura
Purpura actínica
![](http://www.aocd.org/resource/resmgr/ddb_high/actinic_purpura_1_high.jpg)
Purpura de Bateman ou purpura senil
![Senile purpura](http://www.dermnetnz.org/vascular/img/senile-purpura-3-s.jpg)
Purpura fulminans
![](http://www.ijdvl.com/articles/2012/78/2/images/ijdvl_2012_78_2_228_93655_f2.jpg)
Purpura de Henoch- Schonlein
![](http://www.aafp.org/afp/1998/0801/afp19980801p405-f1.jpg)
https://en.wikipedia.org/wiki/Henoch%E2%80%93Sch%C3%B6nlein_purpura
![](https://upload.wikimedia.org/wikipedia/commons/thumb/9/92/Purpura.jpg/220px-Purpura.jpg)
![Characteristic rash of Henoch-Schönlein purpura.](http://img.medscapestatic.com/pi/meds/ckb/47/44747tn.jpg)
http://www.webmd.com/skin-problems-and-treatments/henoch-schonlein-purpura-causes-symptoms-treatment
Purpura de Henoch-Schonlein associada
doença de Graves
Purpura trombocitogenica idiopática
http://www.netdoctor.co.uk/conditions/heart-and-blood/a1176/idiopathic-thrombocytopenic-purpura-itp/
![File:Purpura.jpg](https://upload.wikimedia.org/wikipedia/commons/thumb/9/92/Purpura.jpg/719px-Purpura.jpg)
Purpura trombocitopénica imune
Purpura trombocitopénica trombótica
Quininogenio de alto
peso molecular
Deficiencia do quininogenio de alto peso molecular~
Sindroma de anticorpos antifosfolipidos
Terapia trombolitica
Trombangeite
obliterante ou doença de Buerger
![Thromboangiites obliterans](https://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/18089.jpg)
![](http://circ.ahajournals.org/content/121/16/1858/F1.medium.gif)
Trombastenia de
Glanzman
Trombina
![Schematic diagram of the blood coagulation and protein C pathways. In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa V to Va, fibrinogen to fibrin. In addition, thrombin promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. Thrombin also cross over into the protein C pathway by converting protein C into APC. APC in turn converts factor V into Vi, and VIIIa into VIIIi. Finally APC activates PAR-1 and EPCR.](https://upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Coagulation_full.svg/360px-Coagulation_full.svg.png)
![blood: coagulation](http://media-2.web.britannica.com/eb-media/10/386x370x6710-004-65A2759E.jpg.pagespeed.ic.PsRl32uzKZ.jpg)
![](http://www.haemtech.com/images2/Thrombin.jpg)
Trombocitopenia
http://www.netdoctor.co.uk/conditions/heart-and-blood/a1177/thrombocytopenia-reduced-platelet-count/
![File:Thrombocytopenia 1.jpg](https://upload.wikimedia.org/wikipedia/commons/9/91/Thrombocytopenia_1.jpg)
Plaquetaferese
Transfusao de plaquetas
Trombo
![Blood clot diagram.png](https://upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Blood_clot_diagram.png/300px-Blood_clot_diagram.png)
![n5551339.jpg](https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/media/medical/hw/n5551339.jpg)
Trombocitopenia autoimune
Trombocitopenia
induzida pela heparina
![Figure 4](http://d3md5dngttnvbj.cloudfront.net/content/bloodjournal/112/7/2607/F5.medium.gif)
Trombocitose
Trombocitose essencial
![Peripheral blood smear in essential thrombocytosis](http://img.medscapestatic.com/pi/meds/ckb/01/36801tn.jpg)
Trombocitose secundaria
![](http://www.ascopost.com/media/160413/3.5.43_fig1.jpg)
Trombofilia
![File:Coagulation full.svg](https://upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Coagulation_full.svg/750px-Coagulation_full.svg.png)
Trombolise dirigida por
catetero
Trombomodulina
Trombopoietina
![thrombopoietin](http://www.thrombocyte.com/wp-content/uploads/2015/08/thrombopoietin.gif)
Trombose
Trombose da artéria
basilar
Trombose coronária
![](https://www.thrombosisadviser.com/static/media/images/upload/diagnosing_the_spectrum_of_acs.jpg)
Trombose portal
Budd – Chiari
http://www.chp.edu/our-services/transplant/liver/education/liver-disease-states/budd-chiari-syndrome
Trombose das veias
profundas
![Deep veins](https://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/8733.jpg)
Trombose venosa
cerebral
![File:Gray488.png](https://upload.wikimedia.org/wikipedia/commons/1/1c/Gray488.png)
![Figure 2.](http://circ.ahajournals.org/content/125/13/1704/F2.medium.gif)
![Figure 3.](http://circ.ahajournals.org/content/125/13/1704/F3.medium.gif)
Uroquinase
![](https://upload.wikimedia.org/wikipedia/commons/0/0e/Fibrinolysis.png)
Von Willebrandt